KMID : 1034720100020010019
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Journal of Neurosonology and Neuroimaging 2010 Volume.2 No. 1 p.19 ~ p.26
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Usefulness of Carotid Plaque and Intima-Media Thickness Measurement in Patients with Acute Ischemic Stroke
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Lee Jae-Jung
Hong Jin-Tae Choi Jung-Hye Cha Myoung-Jin Kim Young-Dae Heo Ji-Hoe Nam Hyo-Suk Jung Yo-Han Lee Sung-Ik
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Abstract
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Background: Patients with risk factors for atherosclerosis is prone to develop carotid plaque or increased intima-media thickness (IMT). We explored the association of carotid plaque, atherosclerotic risk factors, frequency of large artery atherosclerosis (LAA) stroke mechanism, and IMT in acute ischemic stroke patients.
Methods: From November 2005 to March 2008, total 633 acute ischemic stroke patients, who were examined with a carotid sonography, were enrolled. The atherosclerotic risk factors and number of plaque, maximum plaque size, and maximum IMT were compared.
Results: Of the 633 patients, 496 (78.3%) had one or more carotid plaques [median 2, interquartile range (IQR) 2-5]. Patients with carotid plaques were older (p<0.001), male predominance (p=0.014), more frequent history of hypertension (p<0.001), diabetes (p<0.001), higher Framingham Stroke Risk Score (14.1¡¾4.5 vs. 10.3¡¾4.6, p<0.001), and increased IMT (0.99¡¾0.16 vs. 0.87¡¾0.24, p<0.001) than patients without carotid plaque. Comparing other subtypes of stroke classification, LAA were more frequently found in higher quartiles of number of plaques (p=0.005), or maximum plaque size (p=0.016) but IMT had no significant difference (p=0.214).
Conclusions: Carotid plaques were associated with atherosclerotic risk factors, and LAA of stroke classification. Either carotid plaque distribution (number) or severity (maximal thickness) in carotid sonography might be used as a predictor of atherothrombotic infarction in patients with acute ischemic stroke.
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KEYWORD
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Carotid plaque, Intima-media thickness, Carotid sonography, Atherosclerosis, Ischemic stroke
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